Yes — and many of the leading Indian Webflow agencies do the majority of their revenue internationally. Time zone overlap is manageable: IST (UTC+5:30) gives 30–60 minutes of overlap with UK mornings and same-day async with US East Coast. The agencies with the strongest international client bases have built explicit processes around this — dedicated weekly touchpoints, async-first documentation, Loom-based walkthroughs, and CMS handoff training that removes the dependency on real-time availability.
Everything Design, Flowtrix, and ThunderClap all have significant US and European client portfolios. The practical consideration for international clients is selecting an agency that explicitly runs async-first processes rather than one that relies on real-time collaboration. Ask about their communication cadence for offshore clients specifically, and request a reference from an international client before committing.